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September 10, 2025TheranosticsOpen Access

Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming

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Authors

YSYang ShenZZZihui ZhengXHXinyao Hu

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Implication

Observational analysis revealed enhanced RT sensitivity in HCC via RGD-modified liposome, indicating potential for improved tumor treatment.

Key Points

  • RGD@LP-Y improved radioimmunotherapy sensitivity in hepatocellular carcinoma through matrix stiffness remodeling.
  • In vitro studies showed significant enhancement of apoptosis and immune activation via RGD@LP-Y and RT combinations.
  • The study used xenograft models to validate the safety and efficacy of RGD@LP-Y with localized radiotherapy.
  • Findings suggest that RGD@LP-Y can effectively manipulate the tumor microenvironment for enhanced therapeutic outcomes.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479d72fhttps://doi.org/10.7150/thno.114892
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