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September 10, 2025TheranosticsOpen Access

Single-cell RNA sequencing reveals that myeloid S100A8/A9 is a novel regulator of the transition from adaptive hypertrophy to heart failure after pressure overload

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Authors

WYWei-Jia YuWJWenxi JiangSLShujing Liu

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Overview

Analysis reveals S100A8/A9 regulates immune cell roles in adaptive hypertrophy and heart failure, suggesting therapeutic target.

Key Points

  • S100A8/A9 significantly increases in heart failure, indicating its role in inflammation and hypertrophy.
  • Results from S100A9 knockout mice demonstrate reduced transition from hypertrophy to heart failure.
  • Single-cell RNA sequencing highlighted the inflammatory response driven by myeloid S100A8/A9 in heart injury.
  • Therapeutic targeting of S100A8/A9 shows potential in preventing cardiac dysfunction related to hypertrophy.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479d714https://doi.org/10.7150/thno.118369
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