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September 10, 2025Investigational New DrugsOpen Access

Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells

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Authors

CTChiou-Ting TsengMKM. Sherry KuWWWei‐Min Wu

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Overview

This study demonstrates enhanced apoptosis in TP53-mutant ovarian cancer cells using HO-3867 and olaparib, suggesting a potential therapeutic strategy.

Key Points

  • Co-treatment with HO-3867 and olaparib significantly increases apoptosis in TP53-mutant ovarian cancer cells, enhancing potential treatment outcomes.
  • Sequential analysis revealed that HO-3867 treatment improved phospho-p53 levels and induced G1 phase arrest, thereby reducing cell viability.
  • Combining HO-3867 with olaparib activates key apoptotic markers, offering a potentially effective strategy against resistant ovarian cancer.
  • Using fallopian tube-derived cancer models and TCGA datasets, the study confirmed the importance of TP53 mutations in treatment response.

Cite This Study

Tseng et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479d309https://doi.org/10.1007/s10637-025-01571-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ixazomib Enhances the Antitumor Effect of Olaparib by Inducing Functional HRD in Ovarian Cancer Cells2025
  2. 2HAMNO and CGK733 as BRCAness-driven candidates exhibit synthetic lethality with olaparib in BRCA-proficient ovarian cancer2026
  3. 3SM08502-Mediated β-Catenin Repression Synergizes with Olaparib to Inhibit Tumor Progression2025
  4. 4Abstract A029: PARP-targeted alpha therapy for the treatment of PARP inhibitor resistant ovarian cancer2025
  5. 5Abstract A020: COPS5 Inhibition sensitizes high-grade serous ovarian cancer to PARP inhibition via R-loop–mediated DNA damage2025