September 10, 2025Scientific ReportsOpen Access

Elevated plasma level of PAI-1 is associated with severe COVID-19

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Retrospective chart review reveals elevated PAI-1 linked to severe COVID-19, suggesting it as a prognostic marker.

Elevated plasma PAI-1 levels significantly correlate with severe COVID-19 outcomes, including ventilator use.
Patients requiring ventilator assistance had notably higher PAI-1 levels, indicating potential prognostic use.
The study involved a retrospective chart review of 113 hospitalized adults, spanning from June 2020 to August 2021.
Findings support PAI-1 as a strong biological marker for assessing the severity of COVID-19 across patients.

Fukahori et al. (2025) studied this question.

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