Variables related to locoregional and distant recurrence in esophageal cancer

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Discussion

Retrospective analysis identifies tumor stage and histology as key factors in recurrence rates.

Advanced tumor stages significantly reduced disease-free survival, impacting overall prognosis.
Patients with squamous cell carcinoma faced higher locoregional recurrence rates than adenocarcinoma counterparts.
Multimodal therapy showed a benefit in disease-free survival for stage III esophageal tumors.
Specific histological subtypes influenced recurrence patterns, suggesting personalized treatment approaches.

Fonseca et al. (2025) studied this question.

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