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September 10, 2025Scientific ReportsOpen Access

Hyperbaric oxygen therapy for long COVID: a prospective registry

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Authors

JBJ. BerkelRLRutger C. LalieuDJDesaline Joseph

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Overview

Prospective registry reveals 56-63% of patients improved after hyperbaric oxygen therapy, suggesting a notable impact on long COVID symptoms.

Key Points

  • A clinically relevant improvement in MCS/PCS occurred in 56-63% of long-term patients after hyperbaric oxygen therapy.
  • Patient-reported measures identified significant positive outcomes, yet 13-19% exhibited worsening mental and physical health.
  • The prospective registry collected data at baseline, post-treatment, and follow-ups at 3 months and 1 year.
  • Cognitive symptoms showed the most improvement, indicating potential benefits of hyperbaric oxygen therapy for long COVID.

Cite This Study

Berkel et al. (2025) studied this question.

synapsesocial.com/papers/68c240deb210217d6479d031https://doi.org/10.1038/s41598-025-11539-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyperbaric Oxygen Treatment of Long Covid: Review of the Evidence and Perspective2025
  2. 2Case Report: Low pressure hyperbaric oxygen therapy as a potential alternative treatment for chronic inflammatory response syndrome: a case study with notable improvements in fatigue, cognition, and testing2025 · 3 citations
  3. 3Hyperbaric oxygen therapy improves post-concussion symptoms in adults with childhood traumatic brain injury: a retrospective cohort study2025 · 1 citations
  4. 4Uptake of Hyperbaric Oxygen Therapy as a Treatment Option in the Management of Selected Medical Conditions Among a Cohort of Doctors2025
  5. 5Longer Health Resort Therapy Improves Outcomes in Long COVID: A Retrospective Study2025 · 3 citations