September 10, 2025Pain

Saphenous–sural nerve injury: a sensory-specific rodent model of neuropathic pain without motor deficits

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Rodent model shows mechanical hypersensitivity in neuropathic pain, preserving motor function and allowing better evaluation.

The saphenous–sural nerve injury model effectively replicates neuropathic pain characteristics without impairing motor function.
C57Bl/6 mice experienced rapid mechanical hypersensitivity, confirmed by behavioral tests with no motor deficits observed.
Cellular analyses highlighted injury-specific ATF3 expression in sensory neurons, indicating robust glial activation in the spinal cord.
This model promotes understanding of pain mechanisms and assists in evaluating potential new therapies for neuropathic pain.

Su et al. (2025) studied this question.

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