September 10, 2025Frontiers in GeneticsOpen Access

Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care

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Discussion

Pilot study shows polygenic risk score influenced physician management and patient education in coronary artery disease.

Integration of polygenic risk scores impacted clinical decision-making in 67% of cases, indicating its relevance.
Physicians frequently raised patient awareness and offered education, with 73 specific instances noted during consultations.
A multicenter, prospective, open-label pilot study involved 150 patients, gathering insights on risk communication strategies.
Findings suggest potential for enhancing risk communication rather than directly altering pharmacologic management.

Ntritsos et al. (2025) studied this question.

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