September 10, 2025CancersOpen Access

Treatment-Free Remission in Ph+ ALL Without Allogeneic Stem Cell Transplantation: Current Evidence and Future Directions

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This review summarizes the evidence on treatment-free remission in Ph+ ALL and implications for TKI discontinuation.

Ph+ ALL, once a high-risk leukemia, now shows potential for long-term survival without transplantation.
Key therapies include tyrosine kinase inhibitors and the bispecific antibody blinatumomab offering new treatment strategies.
Identifying high-risk patients eligible for allogeneic transplantation remains crucial amidst the evolving treatment landscape.
Ongoing research explores durable responses to TKIs, possibly allowing for safe treatment discontinuation in some patients.

Canichella et al. (2025) studied this question.

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