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September 10, 2025PharmaceuticsOpen Access

Personalized Neonatal Therapy: Application of Magistral Formulas in Therapeutic Orphan Populations

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Authors

WSWenwen ShaoÁGÁngela GómezAAAlejandra Alejano

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Overview

This review highlights the potential of magistral formulas to address the needs of neonates, suggesting they may enhance pediatric drug design.

Key Points

  • Magistral formulas may improve treatment options for neonates, addressing significant gaps in available therapies.
  • Pharmacokinetics in neonates differ greatly from adults, complicating medication formulation across different age groups.
  • Exposure to off-label medicines remains prevalent in neonatal care settings, raising safety and efficacy concerns for these vulnerable patients.
  • A lack of authorized medications designed specifically for neonates underscores the urgent need for targeted research and regulatory approval.

Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/68c2409bb210217d6479b705https://doi.org/10.3390/pharmaceutics17080963
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FDA Expert Panel on Infant Formula “Operation Stork Speed” June 2025: Part 3, Marketing of Infant Formulas, Breastfeeding Support, Hypoallergenic Formulas, and Nutrition for Preterm Infants2025
  2. 2Processes applied to the manufacture of infant formulas and foods for special medical purposes2025
  3. 3Infant Formula for the Prevention and Treatment of Neonatal Hypoglycaemia: A Systematic Review and Meta‐Analysis2025
  4. 4Pharmacologic and Clinical Applications of Commonly Administered Medications to Neonates: Focus on Vitamin K, Vitamin D, and Hepatitis B Vaccine Un Updated Review2025
  5. 5Neonatal parenteral nutrition: An expert narrative review of international guidelines and contemporary evidence2026