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September 10, 2025Acta Facultatis Medicae NaissensisOpen Access

Hepatorenal toxicity of different doses of ketorolac administration in adult male rats: A preclinical study

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Authors

FRFatemeh RashidiANAmir NoyaniSOSalma Omidi

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Overview

Preclinical study investigates hepatorenal toxicity of ketorolac in adult male Wistar rats, suggesting dose optimization is crucial.

Key Points

  • High-dose ketorolac administration significantly increases liver and kidney function markers in rats.
  • Significant elevation of ALT and AST levels was observed in the high-dose group compared to control.
  • Low-dose and high-dose ketorolac groups showed increased BUN and creatinine levels compared to normal saline.
  • Study emphasizes the need for careful dosing and monitoring in clinical ketorolac use to avoid toxicity.

Cite This Study

Rashidi et al. (2025) studied this question.

synapsesocial.com/papers/68c2409bb210217d6479b342https://doi.org/10.5937/afmnai42-52465
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