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September 10, 2025Science and Technology of Advanced MaterialsOpen Access

Enhanced cancer immunotherapy via synergistic action of NO-Donor nanoparticles (Nano ARG ) and PD-1 antibody

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Authors

TMTing MeiUniversity of Hong KongXZXin ZhangBeijing University of Chinese MedicineXHXiaolu HouHarbin Medical University

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Implication

Combination treatment shows enhanced anti-tumor activity in cancer models, indicating a novel therapeutic strategy.

Key Points

  • Combination treatment significantly inhibited tumor growth while maintaining safety in models.
  • NanoARGs showed a biphasic effect with high doses inhibiting and low doses promoting tumor growth.
  • The treatment elevated NO levels in tumor tissues and improved immune response with macrophage polarization.
  • PD-1 antibody amplified effects by blocking interactions and reactivating T cells, enhancing therapeutic outcome.

Cite This Study

Mei et al. (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d6479ab4dhttps://doi.org/10.1080/14686996.2025.2538430
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