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September 10, 2025AntibioticsOpen Access

In Vitro Activity of Cefiderocol and Aztreonam/Avibactam Against Gram-Negative Non-Fermenting Bacteria: A New Strategy Against Highly Antibiotic-Resistant Infectious Agents

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Authors

JZJan ZávoraVAVáclava AdámkováASA Studená

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Overview

Retrospective analysis evaluated cefiderocol and aztreonam/avibactam against resistant gram-negative bacteria, highlighting their efficacy.

Key Points

  • Cefiderocol and aztreonam/avibactam showed high susceptibility rates against non-fermenting gram-negative bacteria.
  • Acinetobacter sp. were mostly susceptible to cefiderocol, with isolates clustering around the ECOFF value.
  • Pseudomonas aeruginosa had a notable resistance rate, with three isolates resistant to aztreonam/avibactam.
  • Findings support potential use of these antibiotics in treating infections in immunocompromised patients.

Cite This Study

Závora et al. (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d6479a4a4https://doi.org/10.3390/antibiotics14080762
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