September 10, 2025CureusOpen Access

Role of Lymph Node Dissection in Commonly Diagnosed Solid Organ Malignancies With High Mortality Rates: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Discussion

Systematic review compares lymph node dissection outcomes in various high-mortality cancers, highlighting limited survival benefits.

Lymph node dissection showed no significant overall survival benefit in most cancers analyzed, indicating limited effectiveness.
Of the trials, 31 studies (72.1%) compared lymph node dissection to no dissection, while 12 studies (27.9%) assessed extended versus standard lymphadenectomy.
The systematic review involved randomized controlled trials across high-mortality cancers including prostate and lung, demonstrating varied outcomes.
Findings suggest the need for further research into lymph node metastasis impact, given the observed lack of survival benefit in many malignancies.

Bazargani et al. (2025) studied this question.

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