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September 10, 2025NutrientsOpen Access

The Oral–Gut Microbiota Axis Across the Lifespan: New Insights on a Forgotten Interaction

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Authors

DADomenico AzzolinoFondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoMSMargherita Carnevale SchiancaFondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoLSLuigì SantacroceUniversity of Bari Aldo Moro

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Implication

Review highlights oral and gut microbiota interactions, revealing implications for diseases and nutrition.

Key Points

  • Oral and gut microbiota interactions influence systemic health, causing conditions like inflammatory bowel disease.
  • Pathogenic oral bacteria can enter the gut, especially in weakened individuals, contributing to serious health issues.
  • Short-chain fatty acids and bile acids play vital roles in modulating the microbiota interactions and responses.
  • Dysbiosis in either the oral or gut microbiota can lead to systemic inflammation and exacerbation of diseases.

Cite This Study

Azzolino et al. (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d6479a34fhttps://doi.org/10.3390/nu17152538
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Focus on HPV Infection and the Molecular Mechanisms of Oral Carcinogenesis2021 · 79 citations