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September 10, 2025Journal of XenobioticsOpen Access

Hypertension in People Exposed to Environmental Cadmium: Roles for 20-Hydroxyeicosatetraenoic Acid in the Kidney

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Authors

SSSoisungwan Satarug

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Overview

This review highlights cadmium's effects on hypertension and kidney function, suggesting 20-HETE's role in gender differences.

Key Points

  • Chronic exposure to cadmium is linked to an increased risk of hypertension, particularly in women, and may lead to chronic kidney disease.
  • Cadmium accumulation in proximal tubular cells leads to a sustained drop in glomerular filtration rate and increases albuminuria.
  • The mechanism behind cadmium-induced hypertension may involve 20-hydroxyeicosatetraenoic acid, which acts as a second messenger in the kidneys.
  • Recommendations include using glomerular filtration rate loss and albumin excretion for setting cadmium exposure limits in public health.

Cite This Study

Soisungwan Satarug (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d64799fe1https://doi.org/10.3390/jox15040122
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Environmental Exposure to Cadmium and Lead Exacerbates Kidney Function in People with Diabetes2025
  2. 2Kidney Damage in Diabetics Exposed to Cadmium and Lead: The Emergent Role for β2-Microglobulin2025
  3. 3Enhanced Kidney Damage in Individuals with Diabetes Who Are Chronically Exposed to Cadmium and Lead: The Emergent Role for β2-Microglobulin2025
  4. 4Environmental cadmium exposure aggravates renal fibrosis and reduced renal lipid accumulation in diabetic mice2025
  5. 5Association between Occupational Cadmium Exposure and Markers of Kidney Injury: A Systematic Review and Meta-Analysis2025 · 5 citations