September 10, 2025Annals of Saudi MedicineOpen Access

Alpha-1 antitrypsin in COVID-19 patients: a dual-center screening study in Malaysia

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Alpha-1 antitrypsin levels increase with severity in COVID-19, indicating potential genetic influences.
In COVID-19 patients, 64.9% exhibited the PiMM phenotype, compared to 93.6% in healthy controls.
A case-control study analyzed 282 patients across Malaysia, focusing on A1AT phenotypes and levels.
The findings suggest a need for further exploration of A1AT variants and their role in SARS-CoV-2 response.

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Case-control study assesses A1AT levels across various COVID-19 stages, revealing phenotype diversity.

Musa et al. (2025) studied this question.

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