September 10, 2025Journal of AnesthesiaOpen Access

Neuropathic pain after peripheral nerve injury in rats: a model using sciatic nerve clamping

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Discussion

Experimental model induces neuropathic pain characterized by mechanical allodynia and sensitization.

Clamping the sciatic nerve induced significant neuropathic pain responses in rats, revealing a usable model.
The model showed mechanical allodynia over 21 days and thermal hyperalgesia for 7 days after nerve clamp surgery.
Analysis of the L5 dorsal root ganglion and spinal dorsal horn confirmed increased sensitization following nerve injury.
This new model offers advantages in procedural simplicity and reproducibility for studying neuropathic pain mechanisms.

Kumagai et al. (2025) studied this question.

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