September 10, 2025Oncology LettersOpen Access

Identification of key ferroptosis‑related genes associated with the development of gastric cancer: Prognostic models, molecular mechanisms and potential treatment strategies

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Discussion

Analysis identifies 14 ferroptosis-related genes influencing gastric cancer, highlighting prognostic models and possible treatments.

Fourteen key ferroptosis-related genes were identified as significant predictors of gastric cancer progression.
Top risk genes include NOX4, GABARAPL2, and RBMS1, which may influence the immune microenvironment in gastric cancer.
A combination of gene expression analysis and Cox regression models was used to ascertain gene significance and treatment implications.
Potential drugs targeting multiple key genes in gastric cancer were identified, indicating pathways for future therapeutic strategies.

Wang et al. (2025) studied this question.

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