This study reveals how Rac family small GTPase 3 influences cell-cycle mechanics in hepatocellular carcinoma, suggesting potential therapeutic targets.
Key Points
RAC3 overexpression correlates with advanced hepatocellular carcinoma and reduced overall survival rates.
Knockout of RAC3 suppressed proliferation across 16 hepatocellular carcinoma cell lines, demonstrating its role as an oncogenic driver.
Multiomics integration revealed RAC3’s significant impact on cell-cycle regulation and transcriptional activity via E2F1 binding.
This study highlights the potential of targeting the RAC3 and E2F1 axis for therapeutic interventions in hepatocellular carcinoma.