Multi-omics analysis reveals HMGA1's impact on prognosis and immune microenvironment in HNSCC, highlighting its role as a potential therapeutic target.
Key Points
HMGA1 expression is significantly higher in HNSCC tumor tissue, indicating poor prognosis.
Increased HMGA1 correlates with distinct somatic mutations and elevated tumor mutation burden.
Single-cell analysis demonstrates that HMGA1 is highly enriched in malignant cells in HNSCC.
Our findings suggest HMGA1 could serve as a prognostic marker and therapeutic target in HNSCC.