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September 10, 2025Neurology and TherapyOpen Access

Sequential use of OnabotulinumtoxinA and Erenumab in Chronic Migraine: Retrospective Real-World Report on Bidirectional Switching

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Authors

CHCarolin Luisa HoehneASAysenur SahinLOLucas Hendrik Overeem

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Overview

Retrospective analysis showed sequential switching between onabotulinumtoxinA and erenumab improved outcomes in chronic migraine, indicating potential benefits in treatment plans.

Key Points

  • A very good response was noted in about 18% of patients who switched treatments for chronic migraine.
  • 14 out of 78 patients experienced a very good response, defined as a 50% reduction in headache days.
  • Treatment with onabotulinumtoxinA and erenumab showed distinct but beneficial effects in chronic migraine management.
  • This study highlights the need for more data on the sequencing of migraine therapies for optimal patient outcomes.

Cite This Study

Hoehne et al. (2025) studied this question.

synapsesocial.com/papers/68c23fc3b210217d6479740dhttps://doi.org/10.1007/s40120-025-00803-0
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