Medical Multimorbidity in Patients With Treatment‐Resistant Psychosis and Rare Copy Number Variants: A Retrospective Case Series of 24 Patients

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Patients with treatment-resistant psychosis showed high rates of cardiovascular disorders, with 96% affected.
A significant portion exhibited motor disorders, found in 92% of the cohort, highlighting the extent of multimorbidity.
Comprehensive life course phenotyping included specialized neurobehavioral evaluations to assess health outcomes.
Individual-level multimorbidity supports the complexity of illness progression in psychiatric patients carrying NDD CNVs.

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Retrospective case series reveals high rates of comorbidity in patients with CNVs, indicating long-term health risks.

Dietterich et al. (2025) studied this question.

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