Anticancer and Anti-Inflammatory Effects of Benzothiazole Derivatives Targeting NF-κB/COX-2/iNOS in a Hepatocellular Carcinoma Cell Line

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Benzothiazole derivatives significantly reduce cell proliferation and induce apoptosis in HepG2 cells.
Upon treatment with benzothiazole compounds, IC50 values were identified as 56.98 μM and 59.17 μM at 24 h.
The study confirms that synthetic derivatives impact mitochondrial function and inflammatory markers in liver cancer.
These findings highlight the unique role of benzothiazole derivatives in targeting inflammation and cancer pathways.

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Experimental analysis reveals benzothiazole derivatives reduce NF-κB and COX-2, suggesting therapeutic potential against HCC.

Üremi̇ş et al. (2025) studied this question.

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