September 10, 2025BMC Pulmonary MedicineOpen Access

Serum Krebs von den Lungen-6 as a potential biomarker for early diagnosis of silicosis: a case-control study

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Serum levels of KL-6 are elevated in stage I silicosis patients compared to healthy controls and dust-exposed workers.
KL-6 shows an AUC of 0.770 for distinguishing silicosis patients, with a sensitivity of 80.0% and specificity of 70.0%.
Combination of KL-6, C-reactive protein, and ACE offers the highest diagnostic efficacy among tested biomarkers.
KL-6 levels correlate negatively with lung function, indicating its potential role in monitoring disease progression.

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Case-control study evaluates serum KL-6 and its efficacy in diagnosing silicosis, suggesting significant potential as a biomarker.

Nong et al. (2025) studied this question.

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