September 10, 2025MedicineOpen Access

Mortality risk analysis of patients with depression and hyponatremia upon admission: A STROBE-compliant article from the Cerner Health Facts Database

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Analysis shows higher mortality in depressed patients with hyponatremia, implying critical diagnostic insights.

Mortality rate is 2.65% for depressed patients with hyponatremia, significantly higher than 1.24% for those without hyponatremia.
Statistical analysis included over 1 million patients, with 7.78% being depressed and 32.71% of them presenting hyponatremia upon admission.
Logistic regression identified age, gender, Deyo-CCI score, and multiple comorbidities as key independent factors affecting mortality risk.
The study developed models to predict mortality risk, with Model 1 achieving an AUC of 0.816 and Model 2 achieving an AUC of 0.773.

Hu et al. (2025) studied this question.

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September 10, 2025MedicineOpen Access

View Full Paper

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Authors

Analysis shows higher mortality in depressed patients with hyponatremia, implying critical diagnostic insights.

Mortality rate is 2.65% for depressed patients with hyponatremia, significantly higher than 1.24% for those without hyponatremia.
Statistical analysis included over 1 million patients, with 7.78% being depressed and 32.71% of them presenting hyponatremia upon admission.
Logistic regression identified age, gender, Deyo-CCI score, and multiple comorbidities as key independent factors affecting mortality risk.
The study developed models to predict mortality risk, with Model 1 achieving an AUC of 0.816 and Model 2 achieving an AUC of 0.773.

Hu et al. (2025) studied this question.

View Full Paper

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