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September 10, 2025MedicineOpen Access

Mechanisms of Actinidia chinensis Planch roots in the treatment of breast cancer based on network pharmacology and molecular docking

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Authors

JTJing TongPeking UniversityYDYi DingPurdue University West LafayetteDZDongping ZhangChina Jiliang University

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Implication

Network pharmacology reveals active compounds targeting breast cancer pathways in Actinidia chinensis root, suggesting therapeutic potential.

Key Points

  • Active compounds from Actinidia chinensis root showed potential to target 158 breast cancer-related proteins.
  • Molecular docking revealed binding energies as strong as -9.9 kcal/mol, indicating effective interactions with key targets.
  • Analysis identified hormone stimulus response and kinase activity pathways as significant for breast cancer treatment.
  • Involvement of GSK3β and EGFR in tumor progression suggests targeted pharmaceutical interventions may improve outcomes.

Cite This Study

Tong et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d64796194https://doi.org/10.1097/md.0000000000043560
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