September 10, 2025CureusOpen Access

“Airway-First, Heart-Early” Strategy: Managing Neonatal Dextro-Transposition of the Great Arteries in Pierre Robin Sequence

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Observational case describes airway-first strategy improving outcomes in neonate with d-TGA, suggesting effective management for PRS.

Defined airway-first approach promptly stabilized the infant's airway and improved oxygenation, leading to positive outcomes.
Arterial switch repair on day 10 had significant results, with the infant showing normal neurodevelopment at follow-up.
Transitional renal dysfunction and ventilator-associated pneumonia were successfully managed through coordinated multidisciplinary care.
This case emphasizes that timely intervention for d-TGA in PRS can achieve results comparable to isolated cases in resource-limited settings.

Abeer et al. (2025) studied this question.

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