September 10, 2025PLoS ONEOpen Access

Genotype distribution of human papillomavirus among women with cervical cancer stratified by HIV status in Tanzania

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Cross-sectional study finds high-risk HPV distribution similar by HIV status in women with cervical cancer, indicating need for targeted vaccination.

The prevalence of high-risk HPV is 94% among women with cervical cancer in Tanzania, regardless of HIV status.
HIV-positive women with cervical cancer presented at a significantly younger age of 45 years compared to 57 years for HIV-negative women.
HPV 35 was more common in HIV-positive women, while there was no significant difference in distribution of other HPV genotypes by HIV status.
Over 85% of the participants were infected with HPV 16 and/or 18, indicating a strong potential for targeted vaccination to prevent cervical cancer.

Mrema et al. (2025) studied this question.

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Cross-sectional study finds high-risk HPV distribution similar by HIV status in women with cervical cancer, indicating need for targeted vaccination.