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September 10, 2025Cancer Immunology Research

Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis

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Authors

ZWZiyi WangYZYu ZhangXLXiangdong Li

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Overview

Study demonstrates Trem2's role in the immunosuppressive niche of NASH-driven HCC, suggesting enhanced checkpoint therapy.

Key Points

  • Elevated trem2 expression increases immunosuppressive effects in NASH-driven HCC, obstructing treatment efficacy.
  • Knockout of trem2 in myeloid cells leads to pro-inflammatory macrophage accumulation and enhances NET degradation.
  • Trem2 knockout improves anti-PD1 therapy effects, lowering Treg involvement and boosting anti-tumor responses.
  • Findings highlight potential combinatorial therapies targeting myeloid cells and NETosis for metabolic liver cancer.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64795a4dhttps://doi.org/10.1158/2326-6066.cir-24-1088
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Data from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis2025
  2. 2Supplementary Figure S1 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis2025
  3. 3Supplementary Figure S5 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis2025
  4. 4Supplementary Figure S6 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis2025
  5. 5Supplementary Figure S8 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis2025