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September 10, 2025Gerontology

Analysis of Quantitative Susceptibility Mapping Data for Multi-Site and Multi-Modal Brain Imaging Studies: For Measuring Brain Iron and Its Changes with Age

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Authors

CSChrista SondererCUChidi UgonnaKJKevin A. Johnson

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Overview

Analysis reveals variability in QSM measures across sites, indicating the need for standardization of processing pipelines.

Key Points

  • Results show QSM findings vary significantly with the choice of processing pipeline across multi-site studies.
  • Analyzed data from over 500 participants indicated that ROI selection does not greatly influence inter-site consistency.
  • Variance analysis confirmed that site-to-site variability affects key QSM measures derived from different processing pipelines.
  • The study found consistent correlations between brain iron levels and age within certain regions, despite variability.

Cite This Study

Sonderer et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64795950https://doi.org/10.1159/000546852
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