Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025ACS Applied Bio Materials

Inorganic Polyphosphate Relieves Ulcerative Colitis by Modulating the Gut Microbiota and Metabolites

View Full Paper
Ask AI
Bookmark
Share

Authors

ZWZhicheng WangDalian Ocean UniversityJZJing ZhaoDalian Medical UniversitySHSisi HeZunyi Medical University

Discussion

Loading...

Member takes

Implication

In vivo experiments show inorganic polyphosphate improves gut microbiota and metabolite profiles in UC, indicating a novel therapeutic approach.

Key Points

  • Inorganic polyphosphate notably alleviates ulcerative colitis pathology, enhancing gut health.
  • Supplementation with polyP reduces proinflammatory cytokines, including IL-1β and TNF-α, crucial for therapy.
  • PolyP enhances probiotic-rich gut microbiota while diminishing harmful bacterial populations, promoting health.
  • Modulation of metabolomic profiles by polyP elevates key metabolites essential for intestinal barrier repair.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d6479592bhttps://doi.org/10.1021/acsabm.5c01160
View Full Paper
Ask AI
Bookmark
Share