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September 10, 2025npj Metabolic Health and DiseaseOpen Access

Cave adaptation favors aging resilience in the Mexican tetra

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Authors

ACAnsa E. CobhamAKAlexander KenziorPMPedro Morales‐Sosa

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Overview

Comparative analysis reveals less pronounced aging markers in cavefish, suggesting metabolic shifts impact longevity.

Key Points

  • Cavefish demonstrate less pronounced aging markers compared to surface fish, indicating environmental adaptation effects.
  • Morphological, behavioral, and molecular changes in aging were examined, with insulin receptor mutation showing limited lifespan impact.
  • Aging resilience in cavefish may stem from unique metabolic shifts, particularly regarding mitochondrial function.
  • This study contributes insights into how environmental adaptation influences aging across species.

Cite This Study

Cobham et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d6479554dhttps://doi.org/10.1038/s44324-025-00069-y
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