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September 10, 2025Journal of Pharmaceutical CareOpen Access

Evaluating the Effects of Melatonin on Sleep Quality in Patients with Generalized Anxiety Disorder or Major Depressive Disorders

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Authors

MSMarzieh ShahrabiTSTahereh SorbiSSSina SeyedImani

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Overview

Randomized trial assessed sleep quality changes in GAD and MDD patients, suggesting melatonin may help.

Key Points

  • Melatonin use significantly improved PSQI scores in patients with MDD and GAD after four weeks.
  • Scores on the Groningen Sleep Quality Scale also showed significant improvement between melatonin and placebo groups.
  • Seventy-eight patients participated, with assessments based on validated sleep quality questionnaires.
  • Although findings suggest improvement, there is no conclusive evidence for significant sleep quality enhancement overall.

Cite This Study

Shahrabi et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d6479550chttps://doi.org/10.18502/jpc.v13i2.19306
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