A Case Report of Erythema Nodosum Following Letrozole Administration in a 44-Year-Old Iranian Female Patient with Breast Cancer

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Case report reveals erythema nodosum as a rare adverse effect of letrozole in breast cancer, suggesting further clinical awareness.

Erythema nodosum resolved completely after discontinuing letrozole and administering prednisolone.
The patient was a 63-year-old female with estrogen receptor-positive breast cancer and displayed typical EN symptoms.
Letrozole, an aromatase inhibitor, is a common treatment for postmenopausal estrogen receptor-positive breast cancer.
Early recognition and discontinuation of letrozole were crucial for the patient's recovery from EN.

Abedi et al. (2025) studied this question.

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