September 10, 2025Current Opinion in Neurology

Neurotoxicity from chimeric antigen receptor T-cells: an update on diagnosis and treatment

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Neurotoxicity can occur following CAR T-cell therapy, leading to diverse neurological complications.
Classifications include early-onset ICA, delayed-onset syndromes, and inflammation-related neurotoxicity.
Management requires individualized strategies to maintain neurological function and CAR T efficacy.
Ongoing research targets biomarkers and risk-adjusted treatments for steroid-refractory cases.

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Implication

This review summarizes neurological complications from CAR T-cells, highlighting ICANS and TIAN. It emphasizes tailored interventions for effective management.

Cite This Study

Ursu et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d647954cb https://doi.org/10.1097/wco.0000000000001420

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Implication

This review summarizes neurological complications from CAR T-cells, highlighting ICANS and TIAN. It emphasizes tailored interventions for effective management.

Neurotoxicity from chimeric antigen receptor T-cells: an update on diagnosis and treatment

Key Points

Discussion

Implication

Cite This Study

Neurotoxicity from chimeric antigen receptor T-cells: an update on diagnosis and treatment

Key Points

Discussion

Implication

Cite This Study

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Also Consider