September 10, 2025Journal of CancerOpen Access

An integrated analysis identified mitochondrial ribosomal protein MRPL3 as a potential prognostic biomarker and therapeutic target in pancreatic cancer

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Discussion

Analysis reveals that MRPL3 influences tumor microenvironment and survival in pancreatic cancer, suggesting its potential as a therapeutic target.

High MRPL3 expression is linked to poor prognosis and reduced NK cell activity in pancreatic cancer.
MRPL3 knockout in vitro suppressed cell proliferation, migration, and invasion in pancreatic cancer models.
Kaplan-Meier analysis indicated a significant correlation between MRPL3 levels and overall survival (HR = 2.13).
The findings highlight MRPL3's role in immune evasion and treatment resistance in pancreatic cancer.

Yang et al. (2025) studied this question.

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Analysis reveals that MRPL3 influences tumor microenvironment and survival in pancreatic cancer, suggesting its potential as a therapeutic target.