September 10, 2025Stroke

Diminished Cerebral Oxygen Extraction and Metabolic Rate in Neonates With Hypoxic Ischemic Encephalopathy

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Authors

DJDengrong JiangJohns Hopkins University WGW. Christopher GoldenJohns Hopkins University ZHZhiyi HuJohns Hopkins University

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Implication

Case-control study shows reduced cerebral oxygen extraction and metabolic rate in neonates with hypoxic ischemic encephalopathy, indicating potential biomarkers for treatment planning.

Key Points

Neonates with hypoxic ischemic encephalopathy exhibited significantly lower cerebral oxygen extraction fraction and metabolic rate compared to healthy controls.
The study found that lower oxygen extraction fraction correlates with lower Apgar scores and longer stays in the neonatal intensive care unit among affected neonates.
This observational analysis assessed cerebral metabolism using noncontrast magnetic resonance imaging to compare neonates with hypoxic ischemic encephalopathy and controls.
These results underscore the potential of cerebral oxygen metrics as biomarkers for assessing brain injury in hypoxic ischemic encephalopathy.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64794d47 https://doi.org/10.1161/strokeaha.125.051107

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Implication

Case-control study shows reduced cerebral oxygen extraction and metabolic rate in neonates with hypoxic ischemic encephalopathy, indicating potential biomarkers for treatment planning.

Diminished Cerebral Oxygen Extraction and Metabolic Rate in Neonates With Hypoxic Ischemic Encephalopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Diminished Cerebral Oxygen Extraction and Metabolic Rate in Neonates With Hypoxic Ischemic Encephalopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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