September 10, 2025Cancer Research

Abstract P60: CD47 in Osteosarcoma: Correlation with Metastasis and Macrophage-Mediated Phagocytosis

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CD47 positivity in osteosarcoma biopsies correlated with metastasis at diagnosis, indicating its potential as a therapeutic target.
In a sample of 24 osteosarcoma patients, 20.8% showed CD47 protein expression, suggesting its significance in tumor behavior.
Both in vitro tests and wound-healing assays showed that CD47 antibody (B6H12) inhibits osteosarcoma cell migration and enhances macrophage phagocytic activity.
Further investigations are essential to explore CD47's role and develop innovative immunotherapy strategies against osteosarcoma.

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Retrospective analysis found CD47 positivity correlates with metastasis and macrophage-mediated phagocytosis.

Ko et al. (2025) studied this question.

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