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September 10, 2025International Physical Medicine & Rehabilitation JournalOpen Access

Cannabidiol in the treatment of anxiety disorders: a narrative review

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Authors

EPEduardo Aliende Perin

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Overview

Narrative review highlights cannabidiol's role in treating anxiety disorders, suggesting potential benefits from pharmacological actions.

Key Points

  • Cannabidiol shows potential as an anxiolytic, with promising early findings in anxiety disorders.
  • First-line treatments like cognitive-behavioral therapy and SSRIs often lead to inadequate response and adverse effects.
  • The literature on cannabidiol in treating anxiety is limited and heterogeneous, necessitating further research.
  • Large-scale trials are crucial to clarify efficacy, optimal dosing, and long-term safety of cannabidiol.

Cite This Study

Eduardo Aliende Perin (2025) studied this question.

synapsesocial.com/papers/68c23ed7b210217d647941fahttps://doi.org/10.15406/ipmrj.2025.10.00398
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and Safety of Cannabidiol for Anxiety: A Bibliometric Analysis and Systematic Review2025
  2. 2Effects of Different Cannabinoid Formulations on Anxiety-Related Disorders, and Tourette Syndrome: A Systematic Review and Meta-Analysis2025
  3. 3Endocannabinoid signaling as a potential biomarker in anxiety spectrum disorders – A case series2025
  4. 4Clinical and Cognitive Improvement Following Treatment with a Hemp-Derived, Full-Spectrum, High-Cannabidiol Product in Patients with Anxiety: An Open-Label Pilot Study2025
  5. 5Evidence for Cannabidiol as a Medication for the Treatment of Neurological, Psychiatric, Behavioral and Substance Use Disorders in Adolescents2025