September 10, 2025Asian Journal of ChemistryOpen Access

Synthesis, in vitro and in vivo Antidiabetic Activity of N-Substituted Thiazolidinedione Derivatives

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Discussion

Synthesis and evaluation of thiazolidinedione derivatives for glucose uptake and insulin sensitivity.

Compounds B-TZD-11 and B-TZD-13 significantly enhanced glucose absorption, showcasing antidiabetic potential.
Twelfth out of twenty-two designed thiazolidinediones demonstrated remarkable efficacy, comparable to pioglitazone.
In vivo analysis confirmed substantial glucose-lowering effect and improved insulin sensitivity in diabetic models.
N-substituted thiazolidinedione derivatives showed promising results with favorable modulation of lipid profiles.

Jain et al. (2025) studied this question.

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