Advanced Nanoparticle Platform for Targeted Pancreatic Cancer Therapy: Optimized Gemcitabine Delivery with Biomimetic Coatings

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Fullgem significantly increased intracellular gemcitabine accumulation in PANC-1 cells within one hour, reducing off-target toxicity.
The biomimetic coating improved tumor-targeting specificity and addressed pharmacokinetic limitations like short half-life.
Fullerenes, used in the platform, provide high surface area and stability for effective drug loading and delivery.
PANC-1 cell membranes used as a coating enhanced the efficacy of gemcitabine delivery in treatment-refractory pancreatic cancer.

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Observational analysis shows improved gemcitabine accumulation in PANC-1 cells, suggesting enhanced targeting in pancreatic cancer.

Sara et al. (2025) studied this question.

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