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September 10, 2025Journal of Medical Internet ResearchOpen Access

Large Language Model Symptom Identification From Clinical Text: Multicenter Study

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Authors

AMAndrew McMurryDPDylan PhelanBDBrian E. Dixon

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Overview

Multicenter analysis shows LLMs improve symptom identification accuracy, indicating better generalizability than ICD-10 methods.

Key Points

  • Accuracy of symptom identification improved significantly with large language models over traditional methods.
  • GPT-4 exhibited the highest performance (F1-score=94.0%) in identifying infectious respiratory symptoms compared to ICD-10.
  • LLMs demonstrated strong generalizability across multisite evaluations without the need for extensive customization.
  • The findings suggest that large language models could replace traditional chart review methods in clinical settings.

Cite This Study

McMurry et al. (2025) studied this question.

synapsesocial.com/papers/68c23e94b210217d647934b7https://doi.org/10.2196/72984
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