September 10, 2025Aging and DiseaseOpen Access

Amyloid Beta Regulates Astrocytic Glucose Metabolism and Insulin Signaling in Experimental Models of Alzheimer’s Disease

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Discussion

Experimental models illustrate insulin signaling's role in astrocyte metabolism, indicating potential therapeutic strategies for Alzheimer's disease.

Astrocytic insulin resistance and inflammation were observed in adult PDAPP-J20 mice, indicating metabolic disruption.
Aβ exposure led to proinflammatory activation in astrocytes and difficulties in insulin-induced receptor phosphorylation.
Increased glucose uptake and glycogen storage in amyloid-treated astrocytes suggest altered metabolic functions.
These findings highlight the significant interplay between insulin signaling and astrocyte metabolism in Alzheimer's disease.

Bentivegna et al. (2025) studied this question.

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Experimental models illustrate insulin signaling's role in astrocyte metabolism, indicating potential therapeutic strategies for Alzheimer's disease.