Peculiarities and prognostic significance of epithelial-mesenchymal transition in secondary edematous breast cancers
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Key Points
Lower E-cadherin levels in metastatic secondary edematous breast cancers suggest poorer prognosis and more aggressive behavior.
Positive pancytokeratin expression was noted in all SEBC cases, while CK18 showed heterogeneous expression with significant differences from the control.
Higher epithelial-mesenchymal transition stages were observed in SEBC compared to non-edematous breast cancer, suggesting differing tumor behavior.
Correlation analysis indicated a negative relationship between N-cadherin and E-cadherin expression in secondary edematous breast cancers.
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Implication
Observational analysis highlights E-cadherin as a key marker for treatment in secondary edematous breast cancers, indicating aggressive behavior.