Experimental model reveals how low-frequency JAK2V617F alters hematopoiesis in mice, indicating changes in myeloproliferative neoplasms and clonal hematopoiesis.
Key Points
Low-frequency JAK2V617F clones in unconditioned mice resulted in significant alterations in hematopoiesis.
Data showed an average of 2.7% donor cell chimerism in peripheral blood following bone marrow transplantation.
RNA-seq analyses of bone marrow revealed upregulation of specific transcripts related to myeloid and erythroblast cells.
Loss of osteo-mesenchymal transcripts and trabecular bone was also observed, highlighting implications for myeloproliferative neoplasms.