September 10, 2025Cancer Research CommunicationsOpen Access

Prostate-Specific Antigen Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naive Prostate Cancer Patients

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PSA secretion variability was noted in patients, demonstrating the complexity of using PSA as a biomarker.
In 9 out of 18 patients, PSA levels from CTC varied significantly, with up to 100% of CTC secreting detectable PSA.
Circulating tumor cells were enriched through a specialized process, enhancing the analysis of PSA secretion.
These findings highlight the limitations of PSA monitoring for treatment response due to inherent cell heterogeneity.

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Implication

Study measures PSA secretion from single circulating tumor cells in metastatic castration naive prostate cancer patients, implying variability in biomarker reliability.

Cite This Study

Dathathri et al. (2025) studied this question.

synapsesocial.com/papers/68c23e94b210217d647927de https://doi.org/10.1158/2767-9764.crc-25-0158

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Implication

Study measures PSA secretion from single circulating tumor cells in metastatic castration naive prostate cancer patients, implying variability in biomarker reliability.

Prostate-Specific Antigen Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naive Prostate Cancer Patients

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Discussion

Implication

Cite This Study

Prostate-Specific Antigen Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naive Prostate Cancer Patients

Key Points

Discussion

Implication

Cite This Study

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