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September 10, 2025Journal of Biochemical and Molecular ToxicologyOpen Access

Alamandine: Protective Effects Against Renal Ischemia‐Reperfusion Injury‐Induced Renal and Liver Damage in Diabetic Rats

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Authors

ACAyşe Nuransoy Cengi̇zOÖOnural ÖzhanLTLokman Hekim Tanrıverdi

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Overview

This observational study assesses alamandine's ability to protect against renal ischemia-reperfusion injury in diabetic rats, suggesting potential therapeutic benefits for renal failure.

Key Points

  • Alamandine notably reduced renal and liver damage in diabetic rats following ischemia-reperfusion injury, showcasing its protective effects.
  • Histopathological results indicated significant reductions in tubular dilatation and necrotic changes in groups treated with alamandine.
  • Immunohistochemical analysis revealed decreased interleukin-6 and caspase-3 levels in the alamandine group compared to the I/R group.
  • Overall, the protective effect of alamandine highlights its potential in developing therapies for diabetic renal failure.

Cite This Study

Cengi̇z et al. (2025) studied this question.

synapsesocial.com/papers/68c23e94b210217d647926b0https://doi.org/10.1002/jbt.70423
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