September 10, 2025Journal of Medical SciencesOpen Access

Advanced Peptide Receptor Radionuclide Therapy to Overcome Refractory Hypoglycemic Insulinoma: A Case Report and Review of the Literature

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Discussion

Case report shows significant regression of liver metastases and resolution of hypoglycemia, indicating potential of PRRT.

After four courses of peptide receptor radionuclide therapy, regression of liver masses occurred, resolving hypoglycemia.
The patient's quality of life drastically improved, eliminating the need for antihypoglycemic medications.
Initial treatments with octreotide and everolimus only offered partial relief from hypoglycemia without impacting tumor size.
This case highlights the effectiveness of peptide receptor radionuclide therapy in treating refractory insulinoma.

Huang et al. (2025) studied this question.

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