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September 10, 2025Virology JournalOpen Access

Investigating the link between HPV genotypes and cervical abnormality incidence in women with HPV infections: insights from a leading referral centre

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Authors

ZSZ SadeghiIran University of Medical SciencesAAAmir AboofazeliSSSheida Sarrafzadeh

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Implication

Cross-sectional analysis identifies HPV-16 as a major predictor of cervical intraepithelial neoplasia in women, suggesting tailored preventive strategies.

Key Points

  • HPV-16 is significantly associated with severe CIN outcomes, showing an odds ratio of 2.88.
  • Among participants, abnormal CIN was found in 52.4%, with CIN I at 31.1%, CIN II at 11.4%, and CIN III at 10.0%.
  • Smoking increased the risk of severe CIN with an odds ratio of 1.53, indicating a crucial risk factor.
  • Older age and later sexual debut correlate with improved CIN outcomes, emphasizing the need for early detection.

Cite This Study

Sadeghi et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d647922c0https://doi.org/10.1186/s12985-025-02858-9
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